The Naval Sea Systems Command, Naval Air Systems Command, Space and Naval Warfare Systems Command, Naval Supply Systems Command, Military Sealift Command, Naval Facilities Engineering Command, Naval Supply Systems Command, Strategic Systems Programs, and the United States Marine Corps, along with their Warfare Centers, field activities and affiliated Program Executive Offices (PEOs) have the ability to use the SeaPort-e system as ordering offices. There has been no centralization of requirements determination or acquisition as a result of SeaPort-e.

Navy Virtual Syscom Command members Naval Air Systems Command, Naval Sea Systems Command, Space and Naval Warfare Systems Command, and Naval Supply Systems Command States have designated SeaPort-e as the mandatory acquisition vehicle of choice for competitive acquisition of Engineering, Financial and Program Management services. This designation allows for logical transition of services procurements in these functional areas to the SeaPort-e vehicles and provides contracting offices the latitude to use alternate acquisition vehicles if it is determined to be in the best interest of the Government. This supports Department of the Navy initiatives to implement cost-effective integrated business practices across the Department.